Window of Susceptibility for Zika-Induced Microcephaly Identified by Temporal Gene Analysis

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Abstract:

Increased understanding of developmental disorders of the brain has shown that genetic mutations, environmental toxins and biological insults typically act during developmental windows of susceptibility. Through analysis of developmental time-course gene expression data derived from human pluripotent stem cells, with disease association, pathway, and protein interaction databases, we identify windows of developmental time that appear most vulnerable to a specific insult, and therefore, the time periods for productive interventions. The results are displayed as interactive Susceptibility Windows Ontological Transcriptome (SWOT) Clocks illustrating disease susceptibility over developmental time. Using this method, we determine the likely windows of susceptibility for multiple neurological disorders, including Zika-induced microcephaly. We find that genes impacted by Zika infection are most active in the earliest stages of neural development, prior to cerebral cortex layer formation.

History

DateCreated ByLink
April 10, 2017
09:44:23
John S. EricksonDownload

Related Projects:

CHEAR Project LogoChild Health Exposure Analysis Repository (CHEAR)
Principal Investigator: Deborah L. McGuinness
Co Investigator: Kristin Bennett
Description: Child Health Exposure Analysis Repository Data Science Semantics
SemNExT LogoSemantic Numeric Exploration Technology (SemNExT)
Principal Investigator: Kristin Bennett and Deborah L. McGuinness
Description: SemNExT combines numeric analysis of data with semantic understanding and explanation technologies to provide a holistic means of exploring robust datasets.

Related Research Areas:

Health Informatics
Lead Professor: Deborah L. McGuinness
Description:

Health informatics is "the interdisciplinary study of the design, development, adoption and application of IT-based innovations in healthcare services delivery, management and planning." Procter, R. Dr. (Editor, Health Informatics Journal, Edinburgh, United Kingdom). (From the U.S. National Library of Medicine)


Concepts: None.