KSL-95-17 + redirect page
Finding an average core structure: Application to the globins + Has identifier
Finding an average core structure: Application to the globins + Ksl tr id
Finding an average core structure: Application to the globins + Number
| Finding an average core structure: Application to the globins |
Bibtype
techreport
Has publishing details
February,1995
Has title
Finding an average core structure: Application to the globins
Has where published
KSL-95-17
Has year
1995
Title
Finding an average core structure: Application to the globins
Year
1995
Abstract
We present a procedure for automatically i … We present a procedure for automatically identifying from a set of aligned protein structures a subset of atoms with only a small amount of structural variation, i.e., a core. We apply this procedure to the globin family of proteins. Based purely on the results of the procedure, we show that the globin fold can be divided into two parts. The part with greater structural variation consists of the residues near the heme (the F helix and parts of the G and H helices), and the part with lesser structural variation (the core)forms a structural framework similar to that of the repressor protein (A, B,and E helices and remainder of the G and H helices). Such a division is consistent with many other structural and biochemical findings. In addition,we find further partitions within the core that may have biological significance. Finally, using the structural core of the globin family as a reference point, we have compared structural variation to sequence variation and shown that a core definition based on sequence conservation does not necessarily agree with one based on structural similarity. e with one based on structural similarity.
Note
Medical Computer Science
Address
Stanford, CA, USA +
Author
Russ B. Altman and Mark Gerstein +
Has author
Russ B. Altman and Mark Gerstein +
Has identifier
Finding an average core structure: Application to the globins +
Institution
Knowledge Systems, AI Laboratory +
Ksl tr id
Finding an average core structure: Application to the globins +
Month
February +
Number
Finding an average core structure: Application to the globins +
Process note
NO +
Categories KSL Technical Report +, Publication +, Technical Report +
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