KSL-94-06 + redirect page
Compositional Characteristic of Disordered Regions in Proteins + Has identifier
Compositional Characteristic of Disordered Regions in Proteins + Ksl tr id
Compositional Characteristic of Disordered Regions in Proteins + Number
| Compositional Characteristic of Disordered Regions in Proteins |
Bibtype
techreport
Has publishing details
February,1994
Has title
Compositional Characteristic of Disordered Regions in Proteins
Has where published
KSL-94-06
Has year
1994
Title
Compositional Characteristic of Disordered Regions in Proteins
Year
1994
Abstract
Many high resolution protein structures de … Many high resolution protein structures derived from crystallographic studies contain regions in which the temperature factor (or B-factor, a measure related inversely to occupancy) is large. These regions can have low occupancy for two (not mutually exclusive) reasons; either there is motion within the individual molecules which smears out the density overtime, or there are numerous specific conformations adopted by different molecules within the lattice, and therefore the conformations are averaged over the population. In either case, these regions of low occupancy are examples of protein substructures in which there is no single stable conformation, but either a dynamic, flexible set of conformations, or a relatively static set of alternative conformation. These regions may therefore contain valuable information about the ways in which protein structural stability can be achieved. In this paper, we have investigated the characteristics of high B-factor regions within otherwise well-resolved protein structures. Most noteworthy, we have shown that amino acids LYS,SER, GLN, ALA, GLU, PRO, ASN, ASP and ARG occur more frequently in disordered regions, that 40% of disordered residues are in coil conformation (with as much as 30% in a regular repeating secondary structure such as alpha-helix or beta-strand), and that disordered amino acids make on average 2.6 fewer intersidechain contacts than ordered residues. rsidechain contacts than ordered residues.
Note
Updated April 1995.
Author
Russ B. Altman and Christopher Hughes and Oleg Jardetzky +
Has author
Russ B. Altman and Christopher Hughes and Oleg Jardetzky +
Has identifier
Compositional Characteristic of Disordered Regions in Proteins +
Institution
Knowledge Systems, AI Laboratory +
Ksl tr id
Compositional Characteristic of Disordered Regions in Proteins +
Month
February +
Number
Compositional Characteristic of Disordered Regions in Proteins +
Process note
YES +
Categories KSL Technical Report +, Publication +, Technical Report +
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