Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure

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Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure +  Has identifier

Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure +  Ksl tr id

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Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure

Bibtype  techreport

Has publishing details  March,1986

Has title  Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure

Has where published  KSL-86-28

Has year  1986

Title  Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure

Year  1986

Abstract  The determination of protein tertiary stru The determination of protein tertiary structure can be described as a three-dimensional spatial arrangement task similar to many other physical design tasks. For protein structure the task is to arrange parts of the protein subject to a set of undetermined and imprecise constraints. A representation is described that allows this task to be treated as a constraint satisfaction problem. Node consistency algorithms, developed mostly in the field of computer vision, are applied to the solution of a small protein fragment called the lac repressor headpiece, using data obtained from nuclear magnetic resonance spectroscopy. Application of these algorithms, together with heuristic methods of control and refinement, greatly reduces the combinatorics of constraint satisfaction, and should be useful for other physical design problems as well. or other physical design problems as well.

Note  Working Paper 14 pages.

Author  James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky +

Has author  James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky +

Has identifier  Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure +

Institution  Knowledge Systems, AI Laboratory +

Ksl tr id  Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure +

Month  March +

Number  Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure +

Process note  YES +

Categories  KSL Technical Report +, Publication +, Technical Report +

 

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