Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing Regimens

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Citation: Leslie A. Lenert and Lewis B. Sheiner and Terrence F. Blaschke. (1988) Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing Regimens. In KSL-88-76, 1988.

Publication techreport ( Edit )
type Technical Report
bibtype techreport
Bibtex basics
author Leslie A. Lenert and Lewis B. Sheiner and Terrence F. Blaschke
title Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing Regimens
number KSL-88-76
institution Knowledge Systems, AI Laboratory
year 1988
Bibtex more
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abstract Many clinically useful drugs have a narrow range of blood concentrations which are both safe and efficacious. Inter-individual and intra-individual variations in drug disposition are important factors causing blood concentrations of drug to fall outside of the therapeutic range. Modeling of the pharmacokinetics of the individual offers an effective approach to the problem of variation in drug disposition. Previous approaches for the modeling of individual pharmacokinetics have required either extensive computations or access to computer software and hardware in the clinical environment, and special expertise to interpret the results. This paper describes a prototype computer program, PK Monitor, which can, when connected with an appropriate interface, automatically monitor drug dosing and recommend changes that may be required to obtain blood concentrations in the therapeutic range. The software can also detect the occurrence of change in drug disposition which will lead to concentrations outside of the terapeutic concentration measurements. This program will be an integral part of the MENTOR therapeutic monitoring system of programs. PK Monitor awaits a complete evaluation with the rest of the MENTOR system, but preliminary simulations suggest reasonable sensitivity and specificity in monitoring for unexpected data and change.

KSL Technical Report ID: KSL-88-76
Facts about Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing RegimensRDF feed
Abstract Many clinically useful drugs have a narrow … Many clinically useful drugs have a narrow range of blood concentrations which are both safe and efficacious. Inter-individual and intra-individual variations in drug disposition are important factors causing blood concentrations of drug to fall outside of the therapeutic range. Modeling of the pharmacokinetics of the individual offers an effective approach to the problem of variation in drug disposition. Previous approaches for the modeling of individual pharmacokinetics have required either extensive computations or access to computer software and hardware in the clinical environment, and special expertise to interpret the results. This paper describes a prototype computer program, PK Monitor, which can, when connected with an appropriate interface, automatically monitor drug dosing and recommend changes that may be required to obtain blood concentrations in the therapeutic range. The software can also detect the occurrence of change in drug disposition which will lead to concentrations outside of the terapeutic concentration measurements. This program will be an integral part of the MENTOR therapeutic monitoring system of programs. PK Monitor awaits a complete evaluation with the rest of the MENTOR system, but preliminary simulations suggest reasonable sensitivity and specificity in monitoring for unexpected data and change. monitoring for unexpected data and change.
Author Leslie A. Lenert and Lewis B. Sheiner and Terrence F. Blaschke  +
Bibtype techreport  +
Has author Leslie A. Lenert and Lewis B. Sheiner and Terrence F. Blaschke  +
Has identifier KSL-88-76  +
Has publishing details 1988  +
Has title Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing Regimens  +
Has where published KSL-88-76  +
Has year 1988  +
Institution Knowledge Systems, AI Laboratory  +
Ksl tr id KSL-88-76  +
Number KSL-88-76  +
Process note YES  +
Title Improving Drug Dosing in Hospitalized Patients: Automated Modeling of Pharmacokinetcs for Individualization of Drug Dosing Regimens  +
Year 1988  +
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