Compositional Characteristic of Disordered Regions in Proteins

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Citation: Russ B. Altman and Christopher Hughes and Oleg Jardetzky. (1994) Compositional Characteristic of Disordered Regions in Proteins. In KSL-94-06, February,1994.

Publication techreport ( Edit )
type Technical Report
bibtype techreport
Bibtex basics
author Russ B. Altman and Christopher Hughes and Oleg Jardetzky
title Compositional Characteristic of Disordered Regions in Proteins
number KSL-94-06
institution Knowledge Systems, AI Laboratory
year 1994
month February
Bibtex more
note Updated April 1995.
Access Paper
abstract Many high resolution protein structures derived from crystallographic studies contain regions in which the temperature factor (or B-factor, a measure related inversely to occupancy) is large. These regions can have low occupancy for two (not mutually exclusive) reasons; either there is motion within the individual molecules which smears out the density overtime, or there are numerous specific conformations adopted by different molecules within the lattice, and therefore the conformations are averaged over the population. In either case, these regions of low occupancy are examples of protein substructures in which there is no single stable conformation, but either a dynamic, flexible set of conformations, or a relatively static set of alternative conformation. These regions may therefore contain valuable information about the ways in which protein structural stability can be achieved. In this paper, we have investigated the characteristics of high B-factor regions within otherwise well-resolved protein structures. Most noteworthy, we have shown that amino acids LYS,SER, GLN, ALA, GLU, PRO, ASN, ASP and ARG occur more frequently in disordered regions, that 40% of disordered residues are in coil conformation (with as much as 30% in a regular repeating secondary structure such as alpha-helix or beta-strand), and that disordered amino acids make on average 2.6 fewer intersidechain contacts than ordered residues.

KSL Technical Report ID: KSL-94-06
Facts about Compositional Characteristic of Disordered Regions in ProteinsRDF feed
Abstract Many high resolution protein structures de … Many high resolution protein structures derived from crystallographic studies contain regions in which the temperature factor (or B-factor, a measure related inversely to occupancy) is large. These regions can have low occupancy for two (not mutually exclusive) reasons; either there is motion within the individual molecules which smears out the density overtime, or there are numerous specific conformations adopted by different molecules within the lattice, and therefore the conformations are averaged over the population. In either case, these regions of low occupancy are examples of protein substructures in which there is no single stable conformation, but either a dynamic, flexible set of conformations, or a relatively static set of alternative conformation. These regions may therefore contain valuable information about the ways in which protein structural stability can be achieved. In this paper, we have investigated the characteristics of high B-factor regions within otherwise well-resolved protein structures. Most noteworthy, we have shown that amino acids LYS,SER, GLN, ALA, GLU, PRO, ASN, ASP and ARG occur more frequently in disordered regions, that 40% of disordered residues are in coil conformation (with as much as 30% in a regular repeating secondary structure such as alpha-helix or beta-strand), and that disordered amino acids make on average 2.6 fewer intersidechain contacts than ordered residues. rsidechain contacts than ordered residues.
Author Russ B. Altman and Christopher Hughes and Oleg Jardetzky  +
Bibtype techreport  +
Has author Russ B. Altman and Christopher Hughes and Oleg Jardetzky  +
Has identifier KSL-94-06  +
Has publishing details February,1994  +
Has title Compositional Characteristic of Disordered Regions in Proteins  +
Has where published KSL-94-06  +
Has year 1994  +
Institution Knowledge Systems, AI Laboratory  +
Ksl tr id KSL-94-06  +
Month February  +
Note Updated April 1995.
Number KSL-94-06  +
Process note YES  +
Title Compositional Characteristic of Disordered Regions in Proteins  +
Year 1994  +
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