Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure

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Citation: James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky. (1986) Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure. In KSL-86-28, March,1986.

Publication techreport ( Edit )
type Technical Report
bibtype techreport
Bibtex basics
author James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky
title Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure
number KSL-86-28
institution Knowledge Systems, AI Laboratory
year 1986
month March
Bibtex more
note Working Paper 14 pages.
Access Paper
abstract The determination of protein tertiary structure can be described as a three-dimensional spatial arrangement task similar to many other physical design tasks. For protein structure the task is to arrange parts of the protein subject to a set of undetermined and imprecise constraints. A representation is described that allows this task to be treated as a constraint satisfaction problem. Node consistency algorithms, developed mostly in the field of computer vision, are applied to the solution of a small protein fragment called the lac repressor headpiece, using data obtained from nuclear magnetic resonance spectroscopy. Application of these algorithms, together with heuristic methods of control and refinement, greatly reduces the combinatorics of constraint satisfaction, and should be useful for other physical design problems as well.

KSL Technical Report ID: KSL-86-28
Facts about Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary StructureRDF feed
Abstract The determination of protein tertiary stru … The determination of protein tertiary structure can be described as a three-dimensional spatial arrangement task similar to many other physical design tasks. For protein structure the task is to arrange parts of the protein subject to a set of undetermined and imprecise constraints. A representation is described that allows this task to be treated as a constraint satisfaction problem. Node consistency algorithms, developed mostly in the field of computer vision, are applied to the solution of a small protein fragment called the lac repressor headpiece, using data obtained from nuclear magnetic resonance spectroscopy. Application of these algorithms, together with heuristic methods of control and refinement, greatly reduces the combinatorics of constraint satisfaction, and should be useful for other physical design problems as well. or other physical design problems as well.
Author James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky  +
Bibtype techreport  +
Has author James F. Brinkley and Craig Cornelius and Russ B. Altman and Barbara Hayes-Roth and Olivier Lichtarge and Bruce S. Duncan and Bruce G. Buchanan and Oleg Jardetzky  +
Has identifier KSL-86-28  +
Has publishing details March,1986  +
Has title Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure  +
Has where published KSL-86-28  +
Has year 1986  +
Institution Knowledge Systems, AI Laboratory  +
Ksl tr id KSL-86-28  +
Month March  +
Note Working Paper 14 pages.
Number KSL-86-28  +
Process note YES  +
Title Application of Constraint Satisfaction Techniques to the Determination of Protein Tertiary Structure  +
Year 1986  +
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